The gallery was founded in 1985 by co-owners Lawrence R. Luhring and Roland J. Augustine. Its principal focus is the representation of an international group of contemporary artists whose diverse practices include painting, drawing, sculpture, video, photography, and performance.

Luhring Augustine established a new location at 25 Knickerbocker Avenue in Bushwick, Brooklyn in 2012. This second site houses an exhibition space for large-scale installations and long-term projects. Its exhibition schedule reflects Luhring Augustine's continued focus on an international program of contemporary art.